Lupus erythematosus
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ReferencesAt identificere og klassificere cutaneous lupus erythematosus (CLE) udgør diagnostiske udfordringer og adskiller den fra systemic lupus erythematosus med hudinvolvering. Nylige undersøgelser kaster lys over genetiske, miljømæssige og immunologiske faktorer, der ligger til grund for CLE. Lægemiddelinduceret udbrud er specifikt dukket op som en af de vigtigste triggere for CLE. Behandlingen involverer topiske og systemiske terapier, herunder lovende biologiske lægemidler som belimumab, rituximab, ustekinumab, anifrolumab og BIIB059, med demonstreret effekt i kliniske forsøg.
Diagnostic challenges exist in better defining cutaneous lupus erythematosus (CLE) as an independent disease distinct from systemic lupus erythematosus with cutaneous features and further classifying CLE based on clinical, histological, and laboratory features. Recent mechanistic studies revealed more genetic variations, environmental triggers, and immunologic dysfunctions that are associated with CLE. Drug induction specifically has emerged as one of the most important triggers for CLE. Treatment options include topical agents and systemic therapies, including newer biologics such as belimumab, rituximab, ustekinumab, anifrolumab, and BIIB059 that have shown good clinical efficacy in trials.
Diagnostic challenges exist in better defining cutaneous lupus erythematosus (CLE) as an independent disease distinct from systemic lupus erythematosus with cutaneous features and further classifying CLE based on clinical, histological, and laboratory features. Recent mechanistic studies revealed more genetic variations, environmental triggers, and immunologic dysfunctions that are associated with CLE. Drug induction specifically has emerged as one of the most important triggers for CLE. Treatment options include topical agents and systemic therapies, including newer biologics such as belimumab, rituximab, ustekinumab, anifrolumab, and BIIB059 that have shown good clinical efficacy in trials.
Cutaneous lupus erythematosus (CLE) dækker forskellige hudproblemer, hvoraf nogle kan være forbundet med bredere sundhedsproblemer. Det er inddelt i forskellige typer, såsom akut CLE (ACLE), subakut CLE (SCLE) og kronisk CLE (CCLE). CCLE omfatter discoid lupus erythematosus (DLE), LE profundus (LEP), chilblain cutaneous lupus og lupus tumidus.
Cutaneous lupus erythematosus (CLE) encompasses a wide range of dermatologic manifestations, which may or may not be associated with the development of systemic disease. Cutaneous lupus is divided into several sub-types, including acute CLE (ACLE), sub-acute CLE (SCLE) and chronic CLE (CCLE). CCLE includes discoid lupus erythematosus (DLE), LE profundus (LEP), chilblain cutaneous lupus and lupus tumidus.
Cutaneous lupus erythematosus (CLE) encompasses a wide range of dermatologic manifestations, which may or may not be associated with the development of systemic disease. Cutaneous lupus is divided into several sub-types, including acute CLE (ACLE), sub-acute CLE (SCLE) and chronic CLE (CCLE). CCLE includes discoid lupus erythematosus (DLE), LE profundus (LEP), chilblain cutaneous lupus and lupus tumidus.
Lupus erythematosus er en gruppe autoimmune sygdomme, der kan påvirke forskellige dele af kroppen. Nogle typer, såsom systemic lupus erythematosus (SLE), påvirker flere organer, mens andre, såsom cutaneous lupus erythematosus (CLE), primært påvirker huden. Vi kategoriserer de forskellige typer af CLE ud fra en kombination af kliniske tegn, vævsundersøgelser og blodprøver, men der er stor variation mellem individer. Hudproblemer udvikler sig ofte som følge af faktorer som sollys, rygning eller visse medikamenter.
Lupus erythematosus comprises a spectrum of autoimmune diseases that may affect various organs (systemic lupus erythematosus [SLE]) or the skin only (cutaneous lupus erythematosus [CLE]). Typical combinations of clinical, histological and serological findings define clinical subtypes of CLE, yet there is high interindividual variation. Skin lesions arise in the course of triggers such as ultraviolet (UV) light exposure, smoking or drugs
Lupus erythematosus comprises a spectrum of autoimmune diseases that may affect various organs (systemic lupus erythematosus [SLE]) or the skin only (cutaneous lupus erythematosus [CLE]). Typical combinations of clinical, histological and serological findings define clinical subtypes of CLE, yet there is high interindividual variation. Skin lesions arise in the course of triggers such as ultraviolet (UV) light exposure, smoking or drugs
Årsagen til lupus erythematosus er ukendt. Hos enæggede tvillinger, hvor den ene er ramt, er der 24 % chance for, at den anden også får sygdommen. Kvindelige kønshormoner, sollys, rygning, D‑vitaminmangel og visse infektioner menes også at øge risikoen.
Behandling kan omfatte NSAID’er, kortikosteroider, immunsuppressiva, hydroxychloroquine og methotrexate. Selvom kortikosteroider er effektive, kan langtidsbrug give bivirkninger.